Thứ Bảy, 22 tháng 10, 2011

Ung thư gan

Ung thư gan là 1 trong 8 ung thư hay gặp nhất trên toàn thế giới, bệnh chiếm 4% trong tổng số các ung thư ở người. Tại Việt Nam, ung thư gan là loại ung thư phổ biến đứng hàng thứ 4 ở cả hai giới. Nguyên nhân gây bệnh chủ yếu là vinh viêm gan B. Đây là căn bệnh rất khó phát hiện ở giai đoạn sớm chính vì vậy việc điều trị cũng ít hiệu quả. Cách tốt nhất phòng chống căn bệnh này là tiêm phòng vacxin viêm gan B.

NGUYÊN NHÂN VÀ CÁC YẾU TỐ NGUY CƠ

Thủ phạm chính gây nên bệnh ung thư gan là virus viêm gan B. Các bằng chứng khoa học đã chứng minh viêm viêm gan B là yếu tố gây ung thư gan trên thực nghiệm. Người bị nhiễm viêm viêm gan B có nguy cơ cao gấp 200 lần so với người không bị nhiễm loại virus này.

Xơ gan do bất cứ nguyên nhân nào cũng là một yếu tố nguy cơ dẫn tới ung thư gan. Uống rượu kéo dài dẫn tới xơ gan là nguyên nhân thường gặp nhất của ung thư gan trên toàn thế giới. Những người bị xơ gan do rượu nếu ngừng uống khoảng 10 năm thì sau đó cũng tiến triển tới ung thư gan. Thực phẩm dự trữ trong môi trường nóng và ẩm dễ sinh ra một loại nấm gọi là Aspergillus flavus, loại nấm này sinh ra Aflatoxin, là chất được biết gây ung thư mạnh trên thực nghiệm. Ung thư tế bào gan cũng xuất hiện ở trên 30% bệnh nhân bị ứ sắt có tính chất di truyền. Tại Việt Nam, hậu quả của chiến tranh để lại với hàng triệu tấn chất độc màu da cam có chứa chất Dioxin cũng là một yếu tố nguy cơ chính gây nên căn bệnh này.

TRIỆU CHỨNG VÀ CHẨN ĐOÁN

Các bệnh nhân ung thư gan ở giai đoạn sớm hầu như không có triệu chứng, khi phát hiện ra thì bệnh đã ở giai đoạn muộn. Đau bụng vùng hạ sườn trái là triệu chứng thường gặp nhất do u lớn Triệu chứng khởi đầu cũng thường gặp là trên các bệnh nhân xơ gan đột ngột xuất hiện biến chứng (cổ chướng, vàng da, xuất huyết tiêu hoá do giãn vỡ tĩnh mạch thực quản). Khi khám bệnh. các bác sỹ có thể sờ thấy gan to, ấn rắn chắc.

Các xét nghiệm thường được làm để chẩn đoán ung thư gan là xét nghiệm máu xác định nồng độ anpha-FP, khi AFP cao trên 500nglml thì rất gợi ý tới ung thư gan. Ngoài ra, các xét nghiệm chẩn đoán hình ảnh như siêu âm, chụp CT scaner ổ bụng có tác dụng xác định vị trí và sự xâm lấn của khối u gan. Xét nghiệm sinh thiết gan bằng chọc kim nhỏ đơn thuần hoặc dưới sự hướng dẫn của siêu âm để chẩn đoán mô bệnh học.

ĐIỀU TRỊ VÀ TIÊN LƯỢNG

Điều trị bệnh nhân ung thư gan tuỳ thuộc vào giai đoạn của ung thư và tình trạng sức khoẻ chung của bệnh nhân. Đối với những trường hợp có khối u nhỏ đơn độc, chức năng gan còn tết, phương pháp điều trị chủ yếu là phẫu thuật cắt bỏ khối u. Tuy nhiên, hầu hết những bệnh nhân ung thư gan cũng bị xơ gan và không thể cắt bỏ khối u được. Các phương pháp điều trị khác như tiêm cồn, hoá chất động mạch gan... cho kết quả rất hạn chế. Đối với các bệnh nhân giai đoạn muộn, điều trị chủ yếu là chống đau và chăm sóc triệu chứng.

Ung thư gan là bệnh có tiên lượng xấu, thời gian sống trung bình từ khi phát hiện khoảng 6 tháng. Chỉ có khoảng 1 % người ung thư gan có nguy cơ sống sót sau 5 năm.

DỰ PHÒNG

Đa số các ung thư gan thường kèm theo nhiễm viêm gan B, để dự phòng căn bệnh này, việc cần làm là thực hiện tiêm vacxin chống lại virus viêm gan B.

Nguồn: http://ungthu.net.vn/?a=benh_detail&id=8

Ung thư gan - những điều cần biết

Ung thư gan - những điều cần biết

Hơn 16.000 người bị ung thư gan mỗi năm ở Hoa kỳ. Nguyên nhân chính xác của ung thư gan chưa được biết rõ , nhưng viêm gan mãn tính và xơ gan là yếu tố nguy cơ ung thư gan.

Các loại ung thư gan:

*Ung thư tế bào gan nguyên phát:


Trên 80% ung thư gan là ung thư tế bào gan nguyên phát, ung thư này xảy ra ở nam gấp đôi nữ và thường gặp ở tuổi trên 50 . Ung thư tế bào gan nguyên phát (HCC) bắt đầu xảy ra từ tế bào gan. Người ta chưa biết chính xác nguyên nhân HCC nhưng viêm gan do siêu vi mãn tính, xơ gan là yếu tố nguy cơ HCC. Xơ gan chiếm 80% truờng hợp HCC. Dạng khác của ung thư gan là ung thư đường mật. Đây là ung thư xuất phát từ ống dẫn mật và nguyên nhân là do viêm xơ chai đường mật nguyên phát.Ung thư đường mật có thể do nhiễm ký sinh trùng , chẳng hạn như sán lá nhỏ. Ung thư này phát triển theo đường dẫn mật , rất khó thấy trên phim X quang.


*Ung thư di căn gan:


Ung thư xuất phát từ tế bào của các phần khác của cơ thể lan đến gan . Ung thư di căn gan có thể từ: ung thư đường tiêu hóa, vú , phổi, ung thư tủy…..Tùy theo cơ quan nào di căn đến gan mà gọi tên , ví dụ từ ung thư phổi thì gọi là ung thư gan thứ phát do di căn từ ung thư phổi.

Triệu chứng của ung thư gan?


Triệu chứng của ung thư gan gồm: mệt , sốt , đau bụng, sụt cân không rõ nguyên nhân, ăn không ngon , dễ chảy máu hay dễ có vết bầm, vàng da, báng bụng.

Ung thư gan được chẩn đoán như thế nào?

Ung thư gan có thể được phát hiện qua cuộc kiểm tra sức khỏe định kỳ. Bác sĩ có thể sờ thấy khối u lớn và cứng trong bụng.
Xét nghiệm máu AFP (alpha fetoprotein). 50---70% người ung thư gan có AFP trong máu cao. AFP cao có thể nghĩ đến ung thư gan nhưng không thể là yếu tố quyết định chắc chắn. Sau khi thấy AFP cao nên làm siêu âm , chụp cắt lớp điện toán (CT) , chụp cộng hưởng từ (MRI), chúng ta sẽ thấy khối u , tuy nhiên chưa xác định chắc chắn u lành tính hay ác tính. Để chẩn đoán chính xác lành hay ác ,phải sinh thiết gan .



Nguyên nhân gây ung thư gan


Người ta chưa biết chính xác nguyên nhân ung thư gan . Tuy nhiên có nhiều yếu tố thuận lợi giúp phát triển ung thư gan, bao gom cả tuổi, phái tính, gia đình. Phái nam bị ung thư nhiều hơn nữ và tỉ lệ tăng dần sau 60 . Những người trong gia đình có nhiều người bị ung thư gan cũng dễ có nguy cơ phát triển ung thư gan.


*Những yếu tố nguy cơ:

- Nhiễm virus viêm gan B , C mãn tính: gây nên viêm gan , xơ gan và phát triển thành ung thư gan. Khoảng 25% những người u gan ở Mỹ có nhiễm siêu vi B. Những người có nguy cơ nhiễm siêu vi C nên được xét nghiệm máu để phát hiện bệnh và điều trị kịp thời , như vậy giúp ngăn ngừa xơ gan và nguy cơ ung thư gan.
- Xơ gan: nguy cơ đưa đến ung thư gan rất lớn. Hơn 80% trường hợp u gan có xơ gan .Uống rượu là nguyên nhân dẫn đến xơ gan nhiều ở Mỹ.
- Bệnh gan ứ sắt: Sự quá tải sắt ở gan. Đây là bệnh di truyền gây rối loạn chuyển hóa sắt. Sự quá tải sắt gây độc cho cơ thể đặc biệt ở gan , gây viêm và chết tế bào gan. Điều này dẫn đến xơ gan và nguy cơ rất cao đưa đến ung thư gan.
- Hút thuốc: đây cũng là yếu tố nguy cơ ung thư gan. Trong khi mối liên quan giữa thuốc lá và ung thư gan chưa được biết rõ ràng , Tổ chức gan mật Hoa Kỳ khuyên mọi người nên ngừng hút thuốc . Lượng thuốc hút mỗi ngày càng nhiều , thời gian hút thuốc càng lâu càng làm tăng nguy cơ ung thư gan.
- Một số hóa chất có nguy cơ gây ung thư gan: vinyl chloride dùng chế plastic, arsenic nhiễm trong nước uống…….
- Lạm dụng thuốc steroid thường xuyên cũng là yếu tố nguy cơ



Tiên lượng cho bệnh nhân ung thư gan?


Tiên lượng phụ thuộc vào nhiều yếu tố bao gồm yếu tố khối u có được chẩn đoán sớm không? Nếu khối u nhỏ có thể điều trị bằng phẫu thuật, tuy nhiên tỉ lệ thành công của phẫu thuật 10----20% . Nếu phẫu thuật không thành công bệnh nhân tử vong trong vòng 3 đến 6 tháng . Tiên lượng ung thư di căn gan rất xấu.



Ung thư gan được điều trị như thế nào


Điều trị ung thư gan rất khó khăn . Triệu chứng ung thư gan thì khó nhận biết chỉ đến khi khối u phát triển nhiều , vì vậy việc phát hiện thường là trễ. Những yếu tố nguy cơ khác như xơ gan , làm cho việc điều trị phẫu thuật khó khăn.
Phẫu thuật có thể cắt bỏ khối u nhỏ , nếu cả khối u được cắt bỏ , khả năng sống còn của bệnh nhân 25%. Tuy nhiên thưiờng rất hiếm thành công vì thường phần lớn gan đã bị xơ.
Ghép gan thì có thể , tuy nhiên nếu ung thư đã di căn thì không thể áp dụng được.
Hóa trị và xạ trị thì hiệu quả rất hạn chế
Một kỹ thuật mới (SIRT) phướng pháp dùng tia xạ chọn lọc với tần số cao đánh trực tiếp vào khối u mà không làm tổn thương mô xung quanh . Thử nghiệm lâm sàng cho thấy SIRT có thể cải thiện triệu chứng và kéo dài sự sống cho bệnh nhân.
Kỹ thuật đông lạnh bằng hóa chất : dùng catheter bơm hóa chất và thuốc doxorubicin vào khối u cũng hứa hẹn nhiều thành công tốt đẹp.



Ung thư gan có thể được ngăn ngừa?


Phòng bệnh là phương pháp tốt nhất chống ung thư gan. Phải nỗ lực làm giảm xơ gan , phát hiện sớm và điều trị viêm gan siêu vi mãn tính. Các thuốc điều trị viêm gan virus mãn tính , thuốc chống siêu vi cũng có thể làm giảm tỉ lệ ung thư gan.

Vaccin chống siêu vi A , B rất cần thiết , đặc biệt với người viêm gan C . Không nên uống rượu. Phải khám sức khỏe định kỳ những người có nguy cơ nhằm phát hiện ung thư gan sớm.

Nguồn: http://www.drthuthuy.com/Faq/Ungthugan.htm

Thứ Năm, 20 tháng 10, 2011

Guidelines for Research Proposals

The proposal should be at least 10 single-spaced typed pages. Additional information may be attached as an annex. The proposal should include the following sections:
COVERING PAGE AND ABSTRACT
title of the project;
name and address of the project leader and institution;
date of submission; and
abstract - a single paragraph summary of the proposal;
RESEARCH PROBLEM This section should provide a clear description of the problem to be investigated, and the questions that will guide the research process. It should include information on:
the scientific and policy relevance of the problem to be investigated;
an overview of the literature related to this problem; and
a statement as to how the research project will contribute to the solution of the problems identified;
RESEARCH OBJECTIVES
General Objectives - the overall aims of the research project; and
Specific Objectives - the elements of the research which are directly addressable by the methodology;
RESEARCH METHODS This section should be 2-3 pages long and describe in detail the research design and procedures to be followed to achieve each research objective. The following information should be included:
the hypotheses to be tested or research questions to be answered;
the variables or factors to be measured or otherwise addressed by the research;
where applicable, a description of the population and samples to be used in data gathering, including explanations of sampling or selection procedures;
the methods to be applied in collecting primary and secondary information, indicating instruments to be used, and sources of information. If draft questionnaires are available, those should be attached;
if economic valuation methods are used, an indication of any relevant biases in these methods, and the means by which these biases would be overcome in this project; and
the procedures and techniques for processing and analysis of information.
Where applicable, due attention should be given to gender as a variable in the research design (e.g. disaggregation of data by gender; assessment of the differential impact of practices or policies, and so on).
Authors should also ensure that the research procedures proposed conform to acceptable ethical standards. For information on ethical considerations, refer to two documents posted at EEPSEA's website:
Ethical consideration for research (general)
Ethical considerations for stated preference studies
EXPECTED RESULTS AND DISSEMINATION These should be specified and could include:
the solution of specific problems upon which the research has focused;
new knowledge in the scientific area under inquiry;
policy formulation and/or implementation; and
methodological development in the field of inquiry.
This section should also describe the ways in which the project's findings will be disseminated. These could include seminars, and publications;
INSTITUTION AND PERSONNEL This section should describe:
the prior experience and training of the researcher or research team, including curriculum vitae;
the role and responsibilities of each member of the research team; and
where applicable, information on the implementing institution(s);
TIMETABLE This section should include a schedule of activities for the duration of the project. Normally, EEPSEA grants will be of 12 months duration; and
BUDGET Given the cost variations in the region, the ceilings for research budgets have been set as follows:
Group 1: Sri Lanka, Vietnam, Cambodia, Lao PDR, PNG -- CAD24,000 Group 2: China, Thailand, Malaysia, Indonesia, Philippines -- CAD35,000
The budget should be submitted in local currency, providing the rate of exchange to Canadian dollars at the time the proposal is submitted. "Budget Notes" should be included for any items requiring justification or clarification. The budget should be divided into two parts: (a) direct research costs and (b) remuneration:
Direct Research Costs
Research Expenses - Research expenses encompass services and materials (including reference materials) required to carry out the research. They can include remuneration to research assistants; vehicle hire; consumable goods or non-capital equipment such as photocopier supplies; maintenance of research equipment; computer services; local travel;
Dissemination - This budget category includes the cost of project-related seminars organized by the recipient to disseminate research results. It also includes the costs of publishing, and distributing reports, such as publications, bibliographies, abstracts, databases, etc;
Support Services - Support services should only encompass those administrative costs that are not directly related to research. They can include clerical, accounting or secretarial help, general office expenses, office accommodation, rent and utility charges, equipment less than 1,000 CAD; communication and postage expenses, computer services of an administrative nature, unrelated to data analysis; photocopying and general office costs;
Overheads - EEPSEA is governed by the administrative policies of IDRC. These do not permit the payment of unspecified overhead charges in addition to support services. The budget may include: (1) support services, as described in (iii); or (2) a unspecified overhead, expressed as a percentage of the total budget but not both. In either case, the amount requested should not exceed 13% of the total budget excluding capital equipment; and
Recipient Contribution - The budget should specify the value of any contributions from the recipient institution or other local funding source to the project. This may include salaries and facilities provided to the researchers; and
Remuneration In addition to direct research costs (as described above), EEPSEA will consider requests for salary support or honoraria for the principal researcher/s, assuming these are consistent with the policies of the researchers' institution. Given the wide range of circumstances facing researchers, there are no fixed limits for remuneration. This section of the budget proposal should indicate and justify the remuneration requested.
Final reports that are published in designated journals are also eligible for bonus payments under EEPSEA's Publication Incentive Program.
Authors may wish to consult the EEPSEA document How to Design a Research Project in Environmental Economics.
Proposals are reviewed in twice-yearly competitions. The deadlines for these are February 1 and August 1. Proposals should be sent by email attachment to dglover@idrc.org.sg and hfrancisco@idrc.org.sg. The file name for the attachment should include the authors' name and date.
How to Design a Research Project in Environmental Economics
Document(s) 4 of 7

by David Glover Economy and Environment Program for Southeast Asia
Preparing a proposal for a research project is a skill we tend to take for granted, although it is rarely taught in university. Written guides are limited to formats and application forms which briefly list the information requirements of a funding agency, but rarely explain why it important to provide that information.
A clear research proposal is important not only because it increases the chances of getting funding but because it is necessary to the design of an efficient project that will produce valid results. Many of the implementation problems that projects encounter could be avoided if the steps needed to carry out the project had been thought through and specified at the proposal stage.
This paper provides suggestions about how a thorough research proposal might be designed. The purpose is not to provide tips on how to fill out the forms. Instead it is to assist researchers in thinking through the steps needed to carry out a project for maximum impact with minimum effort, something that is in the best interests of the researcher as well as the funding agency.
Like most of us, the author has had no formal training in preparing research proposals. The comments made are based on fifteen years of experience in assessing research proposals as a staff member of IDRC. They were prepared for environmental economists and include examples from that field, but the principles are broadly applicable to other social sciences.
This paper is intended to help readers avoid some of the mistakes others have made and to make the research process a little bit easier. Good luck!
Step by Step
Research design is best approached by thinking through the research process in a sequential, step-by-step process. There will inevitably be some iteration and adjustments between steps, but the following is a useful starting point.
The principal steps are:
1. identify a problem 2. ask a clear question 3. limit the scope of the research 4. say what is known and not known about the problem 5. identify the skills and information needed to answer the question 6. select the methods needed to collect & analyse the data 7. explain the kind of results expected and how they will be presented 8. specify the timetable and budget
Before we even address Step 1, we should perhaps ask ourselves "What is the purpose of research?" If asked for a quick reply, many of us would probably say "To collect information". Certainly data gathering is an important part of most research. But it is not its purpose. The purpose of research is to answer a question. Preferably, it should be a question that someone (like a policy maker) needs an answer to in order to make a decision or to solve or avert a problem.
It follows from this that an essential initial step in designing a research project is to identify an important problem and pose a relevant and answerable research question. From this will flow the data requirements to answer the question, from that the methods needed to collect the data, and so on.
1. Identifying a Problem
For policy-oriented research, it is important to frame the problem as a policy maker would. A policy maker usually has the authority to deal with a particular aspect or manifestation of a problem; has only a limited range of instruments to deal with it; or faces pressures from a particular clientele to do something about it. For example, pollution is obviously a problem in most cities. But identifying "pollution" as a problem is not likely to lead to sharply-focused research useful to a policy maker. How would a policy maker frame the problem?
In the example above, it may be that the environmental agency is very concerned about emissions of toxic waste near a school. The problem is to reduce emissions and/or protect the population rapidly. In another case, the environmental agency is worried that the costs of reducing a widespread but non-toxic form of pollution will be excessively high, perhaps pushing firms out of business and creating unemployment. In that case, the problem is not to produce a rapid reduction in pollution but to identify least-cost instruments to achieve moderate reductions. In a third case, the agency may have been given the mandate and authority to deal with pollution, but no budget. In that case, the agency may be particularly interested in policy instruments that reduce pollution while simultaneously generating revenue for the agency (e.g. pollution taxes).
Research can also play a role in defining problems in ways that policy makers may not have conceived. For example, an agency facing a wide range of environmental problems may find itself overwhelmed and unable to set priorities. By assessing the cost of current damages from various kinds or sources of pollution, and the costs of addressing them, a research project could indicate where the highest cost-benefit ratios are to be found and help in ordering priorities.
The different approaches to economic analysis thus lend themselves to different purposes, e.g.:
* cost-benefit analysis - priority setting, choice of investments
* valuation of benefits - advocacy, sensitization, some priority setting
* cost-effectiveness analysis - identifying least-cost solutions.
The most important thing is that the problem should dictate the approach, not vice versa. The project must address an important problem, not apply a technique from its own sake. Many novice researchers, fresh from graduate school, become infatuated with techniques like linear programming, general equilibrium modelling, or valuation and then search for topics to apply them to. (Someone referred to this as the "law of the hammer", according to which a boy, given a hammer, finds everything worth pounding: not only nails but also Ming vases!)
2. Asking A Question
Having identified a real-world problem and framed it in terms relevant to a policy maker, the researcher must then pose an answerable research question or hypothesis. This essentially defines the objective of the project.
For an environmental economics project, this should be an economic question, i.e. one amenable to economic analysis. Economics tends to deal with issues like resource allocation, tradeoffs, and the difference between social and private costs and benefits.
Some of the characteristics of a good question are:
a) It should be a real question, answerable in some form (as opposed to pure description). Projects that seek to "describe the role of..." (...women in development, religion in politics, water in the ocean) tend not to be immediately useful.
b) Better still, it should be susceptible to a simple answer (yes or no; how much; which option should be selected). This also helps the researcher know when the project is finished; open-ended questions lead to open-ended projects.
c) An answer should be feasible with the resources available. It may be necessary to "cut the coat to fit the cloth", narrowing down the question to what the time and budget will allow.
Journalists are taught to answer simple questions in the first paragraph of a story: who, what, where, when, why and how. Researchers are not journalists, but these questions still provide good starting points for environmental economics projects. Interesting questions to pose include:
Who? Who will be affected by a policy or project? Who will pay the costs? Who will benefit?
What? What will it cost to solve the environmental problem? What will it cost not to solve it?
Why? Why do firms, households or governments do the things they do? What are the economic incentives that cause them to engage in environmentally damaging behaviour?
How? How can we change those incentives to change behaviour?
3. Limiting the Scope
One of the most common mistakes in designing a research project is a tendency to make the project too large and ambitious. If the objectives cannot be accomplished with time and resources available, then they should be restricted in some way. Possibilities for limiting the scope of a project include one or more of the following:
a) limit the geographical area
b) match the scope of the project to the mandate of the agency likely to use the results
c) focus on one resource or pollutant
c) focus on on-site effects (E.g. for soil erosion, look only at the effects on farmers suffering the erosion, excluding downstream effects like sedimentation of dams.)
d) conduct a financial rather than economic analysis (i.e. without shadow pricing). This will not provide a sufficient basis for decision-making but could be useful in explaining behaviour.
Estimating benefits can be particularly difficult, involving intangibles like health, aesthetics, biodiversity and so on. A thorough benefits estimation may take more resources than are available for the entire project and leave nothing for policy analysis. Alternatives to rigorous valuation of benefits include:
a) benefits transfer: taking and adjusting values of existing studies in other locations
b) cost-effectiveness analysis: Instead of estimating the value of costs and benefits (damages avoided) from various policies, a researcher might instead compare the costs of meeting a given standard by different means. This will not answer the fundamental question of whether the investment is truly worthwhile but it will allow the identification of the least-cost method of achieving the goal.
c) focus on major impacts: An ecosystem whose conversion is contemplated may include a dozen or more kinds of values (food production, storm protection, biodiversity, etc.). It may be that including only the most important two or three values will be enough to alter a decision. More information would be redundant.
d) "back of the envelope" estimates: It may be possible to do a careful original study of one aspect of the problem, and supplement that with quick and dirty estimates of other aspects.
Clearly, there are important trade-offs here. A narrowly focused project is likely to be more feasible and to produce more reliable estimates. A broader study is likely to attract more interest and have wider policy impact. At the extreme, a project that is too narrowly defined will no longer have an environmental dimension. For example, a cost-benefit analysis that includes only in-site effects, and is done in financial rather than economic terms will simply perpetuate the style of decision-making that led to environmental damage in the past. Limiting the scope of a project in a reasonable fashion calls for careful judgement; there are no simple rules. Whatever shortcuts are taken, these should be explicitly mentioned, not only in the research proposal, but in the final report as well.
4. Describing What is Known and Not Known
Most application forms for research grants include a section called "literature review". This is often seen as a burdensome formality, consisting of citations of two or three journal articles on vaguely similar topics.
In fact, it is very important to ascertain what information already exists on the research topic, in order to make the best possible use of existing data; avoid duplication; and get a clear idea of what resources are needed for new data collection.
Environmental economics is a relatively new field and it is unlikely that a previous study exactly like the one proposed has already been done. But there is usually something in the literature that can be useful to a new project. Possibilities include:
a) theoretical literature related to concepts or methods proposed in the study
b) empirical studies, either in the country to be studied, or in other countries. A good study done elsewhere may serve as a "prototype" and avoid the need to create a new research design from scratch.
c) raw data. It is especially important to know what physical data are available for economic analysis.
Finally, having explained what is known about this topic, what is not known? What is novel about the study proposed? What gap will it fill? The novelty of a new study could lie in the resource, pollutant or ecosystem to be studied; the method/s used (e.g. one valuation technique rather than another); or in the framing of the question (e.g. focusing on benefits of pollution control rather than costs).
Finally, having explained what is known about this topic, what is not known? What is novel about the study proposed? What gap will it fill? The novelty of a new study could lie in the resource, pollutant or ecosystem to be studied; the method/s used (e.g. one valuation technique rather than another); or in the framing of the question (e.g. focusing on benefits of pollution control rather than costs).
5. Identifying Skills and Information Needs
Rarely can a project in environmental economics be done solely by an economist. Collaborators with skills in physical sciences and other disciplines are usually needed. These people should be involved early in the design of the project, to help identify data needs and frame an answerable research question.
The research team should then identify the information (and only the information) needed to answer the research question. (Collecting too much information can be as big a problem as collecting too little.) Generally, one should not ask a question one does not need an answer to, except in early stages of reconnaissance or pre-testing a questionnaire.
6. Selecting Research Methods
This is one of the most important steps in designing a project and one that reviewers will devote the bulk of their attention to. The proposal should be as explicit as possible, identifying the research sites (or candidates for it); sample size for surveys; method for stratification of samples; frequency of surveys (e.g. one-shot or repeated); and so on. Pre-tests of questionnaires are highly recommended. If economic valuation methods are to be used, then the technique/s should be specified and an explanation offered as to how biases, gaps and double counting will be avoided. If more than one technique is to be used, it should be made clear whether the values from multiple techniques will be added to provide full estimates or compared for purposes of cross-checking. Where gender considerations are relevant, these should be addressed in the methodology (e.g. through disaggregation of data; assessment of the differential impact of policies and practices). Methods for data analysis (e.g econometric techniques) should also be specified and any biases or potential problems discussed.
It may be useful to think through the various steps in the research project and specify the method to be used for each step in table at the bottom of this page.
7. Disseminating Results
The design stage is not too soon to begin discussing the expected results with potential users. Involving them early may suggest research questions, facilitate access to data, and increase the likelihood of impact at the end. The proposal should describe any such discussions that have taken place and plans for dissemination, through seminars, publications, policy briefs, media, etc.
For further information on disseminating results effectively to policy makers, academics and journalists, see A Handbook for Disseminating Research Results in Environmental Economics, available from the EEPSEA Secretariat.
8. Planning the Timetable and Budget
The timetable should allow adequate time to carry the project through to completion. The project consists of more than data collection: time for pre-testing, data analysis and writeup is commonly underestimated.
The budget should specify the resources needed to carry out all the tasks specified above. It should be constructed from the "bottom up", not by dividing the total available into plausible proportions. For example, if fieldwork is involved, the budget for that item should be calculated by estimating the number of trips required, their duration and mileage, and so on.
Go With the Flow!
The sequential approach described above will minimize wasted time and avoid dead ends. Posing a clear research question will define information needs. Reviewing previous studies will avoid duplication and suggest promising approaches. Thinking through all the steps in the research process will make it easier to estimate a realistic budget. The result should be an efficient project that avoids major design problems and produces useful results.
Other References
EEPSEA, Guidelines for the Presentation of Research Proposals
EEPSEA, Handbook for Disseminating Research Results in Environmental Economics
D. Glover, Policy Researchers and Policy Makers: Never the Twain Shall Meet? Journal of Philippine Development, Number 38, Vol. XXI , Nos. 1&2, 1994

SOCIAL SCIENCES & MATHEMATIC METHOD - Impact Factor Ranking 2006







Rank Abbreviated ISSN Total Impact Immediacy Articles Cited
  Journal Title   Cites Factor Index   Half-life
1 ECONOMETRICA 0012-9682 12353 2.402 0.415 53 >10.0
2 SOCIOL METHOD RES 0049-1241 808 2.355 0.111 18 >10.0
3 STRUCT EQU MODELING 1070-5511 2549 2.143 0.429 28 7.8
4 MULTIVAR BEHAV RES 0027-3171 1394 2.095 0.174 23 >10.0
5 RISK ANAL 0272-4332 2521 1.938 0.404 114 6.8
6 REV ECON STAT 0034-6535 4112 1.766 0.121 58 >10.0
7 J ECONOMETRICS 0304-4076 4857 1.669 0.218 124 >10.0
8 J R STAT SOC A STAT 0964-1998 1296 1.547 0.341 44 >10.0
9 FINANC STOCH 0949-2984 389 1.267 0.148 27 5.2
10 MATH FINANC 0960-1627 639 1.102 0.219 32 7.6
11 J BUS ECON STAT 0735-0015 1816 1 0.323 31 >10.0
12 J APPL ECONOM 0883-7252 1113 0.978 0.197 61 9.2
13 ECONOMET THEOR 0266-4666 896 0.939 0.235 51 9.5
14 QUANT FINANC 1469-7688 388 0.929 0.158 38 4.5
15 APPL PSYCH MEAS 0146-6216 1836 0.854 0.172 29 >10.0
16 J MATH PSYCHOL 0022-2496 903 0.783 0.439 41 >10.0
17 J PROD ANAL 0895-562X 527 0.763 0.114 35 8.1
18 INSUR MATH ECON 0167-6687 615 0.756 0.097 62 6.2
19 J EDUC BEHAV STAT 1076-9986 357 0.727

8.1
20 OXFORD B ECON STAT 0305-9049 855 0.722 0.195 41 >10.0
21 SYST DYNAM REV 0883-7066 322 0.667 0 12 7.9
22 STUD NONLINEAR DYN E 1081-1826 151 0.661 0.048 21 4.7
23 PSYCHOMETRIKA 0033-3123 3283 0.608 0.286 35 >10.0
24 J MATH ECON 0304-4068 623 0.59 0.017 60 >10.0
25 J MATH SOCIOL 0022-250X 296 0.48 0.182 11 >10.0
26 SOC CHOICE WELFARE 0176-1714 417 0.417 0 75 8.8
27 INT J GAME THEORY 0020-7276 517 0.411 0.025 40 >10.0
28 MATH SOC SCI 0165-4896 369 0.312 0.064 47 8.6
29 THEOR DECIS 0040-5833 309 0.145 0.111 36 >10.0
30 JAHRB NATL STAT 0021-4027 61 0.125 0 30
31 SOCIOL THEOR METHOD 0913-1442 2 0 0 18

Writing a Research Journal Paper

(from http://www.jhu.edu/~matsci/teaching/510.434/writing_a_research_journal_paper.htm)

Writing a Research Journal Paper

Planning the Paper

1. Write the paper based on kernel of knowledge that has been produced

a. Until you can articulate what this kernel is you cannot write the paper!!

2. Work out objective and motivations

a. Objectives: Are you writing a letter to Science, a research paper to Cell, a review article to the trade journal MRS Bulletin, an article in Farmers Weekly?

i. This determines who the readers are

ii. Acts as a guide to technical content

b. Motivations: Is the paper about designing a piece of equipment, a critique of someone else’s work, presentation of original research, a review article, e.t.c.

i. Determines how you treat the subject matter for readers

3. Consolidate data sources

a. Notebooks

b. Progress reports

c. Literature

4. Construct an outline

a. Why?

i. Allows you to organize your thoughts: writing sections piece-meal and combining them into a paper later leads to a fragmented document

ii. Allows you to figure out a sensible arrangement of information irrespective of what actually happened in the laboratory

iii. With many authors: facilitates organization and reduces rewrites

b. How?

i. Start by listing major points

ii. Fill in subtopics

iii. Important that you determine relative importance of different portions of paper and emphasize the strongest technical aspects of the paper

Once you have a working outline, before you start writing:

1. Set up good descriptive headings

2. Prepare figures, tables

a. Where possible use schematics, pictures, graphs and tables rather than words. Select carefully:

i. Don’t put in figures that are of minimal interest/importance

ii. Use Tables when absolute numbers are important

iii. Use Graphs when trends are important

iv. Never present a figure before you mention it in the text

v. Never present a figure you don’t mention in the text


2. Writing the Paper

Remember to

1. Concentrate on your strong sections

a. Results that didn’t yield interesting/important new information should be de-emphasized

b. In journal articles you get no credit for amount of work done (effort)

i. Don’t go for the sympathy vote, concentrate on your best/most interesting data

c. Look to conclusions to get perspective

2. Concentrate on the key ideas that you are trying to get across

3. In journal articles the “process of proof” is emphasized

a. Make sure that you present enough data/results to substantuate claims and arguments that you make

4. Be concise:

o Express ideas in least number of words

o Only give necessary detail

When writing:

1. The key is : Are the conclusions you are drawing reasonable based on the evidence you are presenting?

2. Avoid personal (unsubstantiated) beliefs: be objective

3. Everything must flow together logically: a good idea is to write “stream-of-concience” mode, and edit/ trim later


Specific sections of the paper:

2.1 Choosing a Title

1. Don’t be cute

2. Be short, but descriptive: e.g. “Creep”, is too short but “Diffusional creep in hot pressed Nb/Nb5Si3 microlaminates at 1000C in the low stress regime” is too long

2.2. Authorship

1. Typically the first author did most of the work, and wrote the paper

2. In my field, the last author typically headed up the research group and paid for the work

3. An author must have made a significant contribution to the work

a. Be generous (but be first)

2.3. Writing an abstract:

1. This is the most read part of your paper

2. Must be self contained and unambiguous

3. Keep as short as possible

4. The idea of an abstract is that it is a mini version of the paper

a. Written by stripping away peripheral information and exposing the hard core of your contribution

5. Required elements

a. Statement of problem

b. Explanation of approach

c. Principal result

6. Be careful to exclude statements not substantiated in the paper

7. Style used: so-called “Indicative-informative”: Gives both general information about work and gives specific information about principal findings

8. Language and technical content is ultimately determined by your audience

9. Abstract is used by search engines for finding you paper, i.e. must contain key phrases and words

2.4. Introduction

1. Purpose of introduction is to supply enough information to allow reader to understand and evaluate results of present study without having to refer to previous publications on topic

2. Structure of introduction:

a. Start with general statement of problem area (orient reader)

i. State Nature and Scope of problem investigated

b. Literature review

i. The idea of the literature review is to:

1. Organize a picture of the state of knowledge in research area

2. Give the reader a better understanding of the project and how it fits into the overall picture

c. Rational for project

d. Scope of Manuscript

e. State method of investigation

f. Indication of technical content that follows

g. State major result and principal conclusions

General comments about writing an introduction

o Introduction typically read independent of Abstract

o In Journal articles you need to emphasize the relationship of your work to that of others

o Interested in what you have contributed in framework of existing literature

o Assumed background of audience is very important

o How much background do your readers really need?

o Too much background is perceived as patronizing,

o Too little background is confusing

2.5. Methodology

o Detail experimental design and provide enough detail so that competent worker can reproduce your results (cornerstone of science)

o “Name names” of products and equipment used(?)

o If new protocol, describe in detail, if not else reference

o Details about samples

2.6. Results

o Identify your major findings

o Interpret these thoughtfully in the discussion section

o Structure Used:

o Overall description of experiments (big picture)

o Present the data

§ Present representative data rather than all of it

· Discrimination is the key

§ Use tables, avoid many descriptions

§ Don’t drone on about uninteresting results, mention them

o Make results section short and punchy by avoiding redundancy:

§ Don’t repeat in text what is shown in figures and tables, rather touch on highlights

§ Only present enough results to support your conclusions

§ Discuss and summarize only important results

§ Pay attention to level of detail

· Determined by type of paper and purpose of manuscript e.g. a paper on the design of a piece of equipment has different emphasis to a letter to Science

2.7. Discussion

o The discussion section is the heart of the paper

o Discussion section is essentially a thoughtful interpretation of the results

o Purpose: show relationships among observed facts

o Factual Relationships

§ Because of what we saw…..

o Significance of results:

§ So what?

o Show how results and interpretations agree (or contradict) previously published work

o Present a hypothesis explaining your results, do not recapitulate the results section

o Point out how results support hypotheses, as well as exceptions

o Discuss theoretical and practical implications of your results

o Avoid presenting new results in discussion

o State conclusions clearly and summarize evidence for each conclusion

o End with short summary or conclusion regarding significance of work

2.8. Conclusions

o Both summarize and discuss the significance of your results

o Should be written in such a way that they:

o Explain the net result of your work in a readable form

o Serves as a candid critique of your work by including both the good the bad

o Give directions for future work

o Give the paper a strong closing

o Differ from abstract in that they are more complete

2.11. Acknowledgements

o Acknowledge

o People than made a technical contribution

o People who contributed ideas

o Your sponsors (N.B.)



2.10. References

· When do you reference?

o When information needed to support your point is given elsewhere

o Acknowledge the work of others

o You claim support for your arguments form other published research

· Don’t mess up details of reference (it ruins the citations index)


Other things that you need to know:

· Camera-ready

· Pick a journal

· What happens to papers submitted to journals

o Sent out for review

§ Almost always get comments

§ Given chance to make corrections and return to editors

§ Everybody gets rejected sometimes

o Get galley proofs

§ Return within 48 hours

o Final journal couple of months to years